High Quality Content by WIKIPEDIA articles! It is mostly used to treat breast cancer, ovarian cancer, and bladder cancer. It is also used as conditioning for bone marrow transplantation. During surgery for ovarian cancer peritoneal washings should be done to remove any cancer cells. Microscopic examination of the fluid may indicate if tumour has spread to the peritoneum. Thiotepa may be left in the peritoneum to work as a chemotherapeutic agent.Thiotepa has been used in combinations with cyclophosphamide and carboplatin. Its main toxicity is myelosuppression.The most serious complication of excessive therapy is bone marrow depression, causing leukopenia, thrombocytopenia, and anemia. If WBC count falls to 3,000/mm 3 or less, discontinue use. If the platelet count falls to 150,000/mm 3 , discontinue therapy. In 2006 the National Cancer Institute recommended giving cisplastin and paclitaxel by both the intravenous and intraperitoneal route after ovarian cancer surgery.

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