High Quality Content by WIKIPEDIA articles! Tryptoline, also known as tetrahydro-?-carboline and tetrahydronorharmane, is a natural organic derivative of beta-carboline. It is an alkaloid chemically related to tryptamines. Derivatives of tryptoline have a variety of pharmacological properties and are known collectively as tryptolines.Many tryptolines are competitive selective inhibitors of the enzyme monoamine oxidase type A (MAO-A). 5-Hydroxytryptoline and 5-methoxytryptoline are the most active monoamine oxidase inhibitors (MAOIs) with IC50s of 0.5 ?M and 1.5 ?M respectively, using 5-hydroxytryptamine (serotonin) as substrate.

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