Издательство: | Книга по требованию |
Дата выхода: | июль 2011 |
ISBN: | 978-6-1312-3297-8 |
Объём: | 168 страниц |
Масса: | 276 г |
Размеры(В x Ш x Т), см: | 23 x 16 x 1 |
High Quality Content by WIKIPEDIA articles! The human gene UBR1 encodes the enzyme ubiquitin-protein ligase E3 component n-recognin 1. The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.
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