High Quality Content by WIKIPEDIA articles! Uptown is a popular commercial district in southwestern Minneapolis, Minnesota, centered at the Uptown Theater (the former Lagoon) at the intersection of Hennepin Avenue and Lagoon Avenue. It has traditionally spanned the corners of four neighborhoods, Lowry Hill East, ECCO, CARAG and East Isles neighborhoods, within the Calhoun Isles community. According to the Uptown Association, a group of business owners and landlords, the boundaries of Uptown are Lake Calhoun to the west, Dupont Avenue to the east, 31st Street to the south, and 28th Street to the north.