High Quality Content by WIKIPEDIA articles! U.S. Route 10 is a major divided highway for almost all of its length in the U.S. state of Minnesota. The route runs through the central portion of the state, following closely the alignment of the former Northern Pacific Railway (now BNSF) and connects the cities of Moorhead, Detroit Lakes, Wadena, Little Falls, St. Cloud, Anoka, Saint Paul, and Cottage Grove.