High Quality Content by WIKIPEDIA articles! U.S. Route 22 is an east–west route stretching from Cincinnati, Ohio in the west to Newark, New Jersey in the east. In Pennsylvania, the route runs for 337.60 miles (543.31 km) between the West Virginia state line at Washington County, where it is a limited-access expressway-grade route through the western suburbs of Pittsburgh, to the New Jersey state line at Easton.