High Quality Content by WIKIPEDIA articles! U.S. Route 412 (abbreviated US-412) is a U.S. highway in the south-central portion of the United States, connecting Springer, New Mexico to Columbia, Tennessee. A 504.11 miles (811.29 km) section of the highway crosses the state of Oklahoma, traversing the state from west to east. Entering the state southwest of Boise City, US-412 runs the length of the Oklahoma Panhandle and serves the northern portion of the state`s main body, before leaving the state at West Siloam Springs. Along the way, the route serves many notable cities and towns, including Boise City, Guymon, Woodward, Enid, and the state`s second-largest city, Tulsa.