High Quality Content by WIKIPEDIA articles! U.S. Route 50 (US 50) is a transcontinental highway in the United States, stretching from Sacramento, California in the west to Ocean City, Maryland on the east coast. The Nevada portion crosses the center of state and was named The Loneliest Road in America by Life magazine in July 1986. The name was intended as a pejorative, but Nevada officials seized on it as a marketing slogan. The name originates from large desolate areas traversed by the route, with few or no signs of civilization. The highway crosses several large desert valleys separated by numerous mountain ranges towering over the valley floors, in what is known as the Basin and Range province of the Great Basin.