High Quality Content by WIKIPEDIA articles! U.S. Route 501 (US 501) is a part of the U.S. Highway System that runs from Myrtle Beach, South Carolina to Buena Vista, Virginia. In Virginia, the U.S. Highway runs 111.42 miles (179.31 km) from the North Carolina state line near Cluster Springs north to its northern terminus at US 60 in Buena Vista. US 501 is the primary highway between Lynchburg and both South Boston in Southside Virginia and Durham in North Carolina`s Research Triangle. North of Lynchburg, the highway parallels the James River through the Blue Ridge Mountains to the southern end of the Shenandoah Valley.