High Quality Content by WIKIPEDIA articles! U.S. Route 59 is a north–south United States highway (though it is signed east–west in parts of Texas). A latecomer to the U.S. numbered route system, U.S. 59 is now a border-to-border route, Part of NAFTA Corridor Highway System. It parallels U.S. Route 75 for nearly its entire route, never much more than 100 miles (160 km) away, until it veers southwest in Houston, Texas. Its number is out of place since U.S. 59 is either concurrent with or entirely west of U.S. Route 71.