High Quality Content by WIKIPEDIA articles! In the U.S. State of Nebraska, U.S. Highway 75 is a highway which goes from the Kansas border south of Dawson in the south to the Iowa border in the north at South Sioux City. Portions of the highway are freeway within the Omaha metropolitan area, including an overlap with Interstate 480. Another segment is freeway in the South Sioux City area, an overlap with Interstate 129. Much of the highway parallels the Missouri River.