High Quality Content by WIKIPEDIA articles! State Trunk Highway 22 (often called Highway 22, STH 22 or WIS 22) is a state highway in the U.S. state of Wisconsin. The route`s trajectory is mostly south to north, with the exception of the segment between Shawano and the northern terminus being east–west. It is generally a two-lane surface road providing a connecting route between Waupaca, Shawano, Gillett and Oconto. Various urban sections have multilane segments.